Tuesday, 19 March 2013

Reimer-Tiemann Reaction

The Reimer-Tiemann reaction is an organic reaction used to convert a phenol to an o-hydroxy benzalde-hyde using chloroform, a base, and acid work-up. 

The mechanism begins with abstraction of the proton from chloroform with the base to form a trichlorocarbanion which spontaneously loses a chloride ion to form a neutral dichlorocarbene.  
The base also deprotonates the phenol reagent which then attacks the carbene. 

A series of steps and a final acid work-up result in the o-hydroxy benzaldehyde product. For more click here.

Image Credit: chemistry.tutorvista.com

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