Targeted Synthesis of Natural Products With Light
Photoreactions are driven by light energy and are vital to the
synthesis of many natural substances. Since many of these substances are
also useful as active medical agents, chemists try to produce them
synthetically. But in most cases only one of the possible products has
the right spatial structure to make it effective. Researchers at the
Technische Universitaet Muenchen (TUM) have now developed a methodology
for one of these photoreactions that allows them to produce only the
specific molecular variant desired.
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The bulky Lewis acid (above) shields one side of the substrate (bottom)
pushing the photoreaction in to the direction of the desired product. -
Graphics: Richard Brimioulle / TUM |
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