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Friday, 9 August 2013

IU Chemists' Work Will Aid Drug Design to Target Cancer and Inflammatory Disease

Chemists at Indiana University Bloomington have produced detailed descriptions of the structure and molecular properties of human folate receptor proteins, a key development for designing new drugs that can target cancer and inflammatory diseases without serious side effects.
 
This image shows models of the human folate receptor (top) and antifolate drugs used in chemotherapy (bottom, from left: aminopterin, pemetrexed and methotrexate). (Credit: Charles Dann III / Courtesy of Indiana University)